ABSTRACT
Objective To assess the clinical significance of red blood cell distribution width ( RDW) in patients undergone prostate biopsy.Methods A total of 793 consecutive patients were enrolled, with 359 cases of prostate cancer ( PCa) and 434 cases of benign prostate hyperplasia ( BPH) diagnosed by pathological examination.The difference of RDW level between PCa and BPH patients was analyzed by T-test.Logistic regression was used to evaluate the contributed factors such as RDW, PSA, HB, WBC, PLT, TG and age.Areas under operating characteristic curves ( AUC) were used to compare the predictive power of RDW for the presence of PCa among different PSA level groups.The difference of RDW level was also analyzed in different groups divided by PSA, Gleason score and clinical stage respectively.Simple linear regression analysis was performed to explore the association of RDW with PSA, Gleason score and clinical stage.Results The means of RDW were ( 13.38 ±1.11 )%in patients with PCa which were higher than those with BPH (12.75 ±0.62)%(P20 ng/ml, the highest in the PSA groups.The RDW was positively correlated with increasing risk evaluated by PSA, Gleason score or clinical stage (P20 ng/ml.Therefore, RDW can be used to evaluate the risk of prostate cancer.